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Thiamet-G

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Product #: IN200000

Thiamet-G

Product Details

Other Names (3aR,6S,7R,7aS)-2-(Ethylamino)-5,6,7,7a-tetrahydro-5-(hydroxymethyl)pyrano[3,2-d]thiazole-6,7-diol
CAS # 1009816-48-1
Formula C9H16N2O4S
Molecular Weight 248.3
Purity >95% (NMR)
Description Thiamet-G is a highly selective inhibitor of O-GlcNAc-specific hexosaminidase (O-GlcNAcase) in humans; Thiamet-G may find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in Alzheimer’s disease
Keywords Thiamet-G, N-Acetylglucosamine, GlcNAc, O-GlcNAcase Inhibitor, Monosaccharide, Thiazoline, (3aR,6S,7R,7aS)-2-(Ethylamino)-5,6,7,7a-tetrahydro-5-(hydroxymethyl)pyrano[3,2-d]thiazole-6,7-diol, C9H16N2O4S
References S.A. Yuzwa et al., Nature Chemical Biology 2008, 4, 483-490.
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