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FZD8 (541-550)-STF(541)


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SKU: 1c3b39be0527 Categories: ,

Product #: GP000025

FZD8 (541-550)-STF(541)

Product Details

where T* = Thr* = Sialyl TF = STF = Neu5Acα2-3Galβ1-3GalNAcα-O-Thr
Other Names Frizzled-8, FZD8, APF, Antiproliferative Factor (synthetic glycopeptide)
UniProt ID Q9H461
Formula C66H112N12O30S
Molecular Weight 1585.72
Purity >90% (HPLC)
Description FZD8(UniProt ID Q9H461) synthetic glycopeptide fragment(Thr541-Cys550; UniProt position 541-550, aa length 10) with Sialyl Tf (Neu5Acα2-3Galβ1-3GalNAc) at Thr541. The C-terminus is carboxylic acid. Antiproliferative factor (APF) is a sialoglycopeptide that contains the transmembrane segment of Frizzled 8, a protein encoded by the FZD8 gene. Highly elevated levels of APF have been associated with interstitial cystitis. Abnormal Akt signaling in bladder epithelial cell explants from patients with interstitial cystitis/bladder pain syndrome can be induced by antiproliferative factor treatment of normal bladder cells.
Keywords FZD8 (541-550)-STF(541), N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Threonine, C-Terminus-Acid, STF-Glycopeptide, Frizzled-8, FZD8, APF, Antiproliferative Factor (synthetic glycopeptide), C66H112N12O30S
Shipping Requirement Dry Ice
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