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N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)3-β-D)-OH


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SKU: 3106a3345c80 Categories: ,

Product #: GA231000

N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)3-β-D)-OH

Product Details

Other Names O-GlcNAc / Threonine, Fmoc-L-Thr(GlcNAc(Ac)3-β-D)-OH, N-α-Fmoc-O-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-threonine, Fmoc-Thr(β-D-GlcNAc)-OH, Peracetate, Fmoc-Thr(GlcNAc(Ac)3-β-D)-OH, N-α-Fmoc-O-β-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosyl)-L-threonine
CAS # 160168-40-1
Formula C33H38N2O13
Molecular Weight 670.66
Purity >95% (HPLC)
Description O-GlcNAc on proteins plays fundamental roles as a cellular nutrient and stress sensor and thus central in the etiologies of chronic diseases of aging, including diabetes, cancer and neurodegenerative disease. In dynamic protein glycosylation, reversible β-O-GlcNAc modification of nuclear and cytoplasmic proteins at serine and threonine controls diverse aspects of cell physiology and is conceptually analogous to phosphorylation.
Keywords N-Acetyl-D-glucosamine: Fmoc-Thr(GlcNAc(Ac)3-beta-D)-OH, N-Acetyl-D-Glucosamine, GlcNAc, O-Link, Monosaccharide, Threonine, Blocked, Amino Acid, Ac, O-GlcNAc / Threonine, Fmoc-L-Thr(GlcNAc(Ac)3-beta-D)-OH, Fmoc-Thr(beta-D-GlcNAc)-OH (Peracetate), Fmoc-Thr(beta-D-GlcNAc)-OH (Peracetate), N-alpha-Fmoc-O-beta-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-beta-D-glucopyranosyl)-L-threonine, N-alpha-Fmoc-O-beta-(2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-beta-D-glucopyranosyl)-L-threonine, C33H38N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
References Hart G.W. et al., Annu. Rev. Biochem., 2011, 80, 825-858; Hart G.W., J. Biol. Chem. 2019, 294, 2211-2231.
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