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25mg$950.00In Stock
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50mg$1,500.00In Stock
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100mg$2,500.00In Stock
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250mg$5,000.00In Stock
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STn Antigen: Fmoc-Ser(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester)

$950.00 – $5,000.00

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SKU: b63286ab435b Categories: ,

Product #: GA121015

STn Antigen: Fmoc-Ser(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester)

Product Details

Other Names STn Epitope (Serine), STn Antigen (Serine), Sialyl-Tn Antigen, Fmoc-L-Ser(Neu5Acα(2-6)GalNAc)-OH (Peracetate, Benzyl Ester), Fmoc-Ser(α-L-Neu5Ac(Ac)4-(2-6)-α-D-GalNAc(Ac)2)-OH, Benzyl Ester, Fmoc-Ser(STn)-OH (Bn, peracetate, free acid)
CAS # 914456-67-0
Formula C56H65N3O24
Molecular Weight 1164.12
Purity >95% (HPLC)
Description Tumor-Associated Carbohydrate Antigen (TACA). STn is a sialylated form of the truncated O-glycosylated core determinant Tn with structure: Neu5Acα2-6GalNAcα-O-Ser/Thr. STn results from an early sialylation of the Tn antigen due to overexpression of the enzyme STn synthase (ST6GalNAc-I) and/or disruption of further glycan elongation processes. STn is negligibly expressed in healthy tissues but overexpressed in >80% of human carcinomas. As such, STn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered STn a prime target for cancer immunotherapy.
Keywords STn Antigen: Fmoc-Ser(Neu5Acalpha(2-6)GalNAc)-OH (Peracetate, Benzyl Ester), N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Serine, Blocked, Amino Acid, Ac, Bz, STn Epitope (Serine), STn Antigen (Serine), Sialyl-Tn Antigen, Fmoc-L-Ser(Neu5Acalpha(2-6)GalNAc)-OH (Peracetate, Benzyl Ester), Fmoc-Ser(alpha-L-Neu5Ac(Ac)4-(2-6)-alpha-D-GalNAc(Ac)2)-OH, Benzyl Ester, C56H65N3O24, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
References J. Munkley, Int J Mol Sci. 2016, 17, 275; M. Sletmoen, et al. Glycobiology 2018, 28, 437–442
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