Pack Size Price (USD) Availability Quantity
1mg$500.00In Stock
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2mg$900.00In Stock
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5mg$1,650.00In Stock
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10mg$2,550.00In Stock
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TF Antigen: H-Thr(Gal(β(1-3)GalNAc)-OH

$500.00 – $2,550.00

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SKU: aacd013df2ab Categories: ,

Product #: GA130010

TF Antigen: H-Thr(Gal(β(1-3)GalNAc)-OH

Product Details

Other Names TF Epitope (Threonine), T Antigen (Threonine), Galβ(1-3)GalNAc-α-1-O-Threonine, Thomsen–Friedenreich Antigen
CAS # 60280-58-2
Formula C18H32N2O13
Molecular Weight 484.45
Purity >95% (NMR)
Description Tumor-Associated Carbohydrate Antigen (TACA). TF is a truncated O-glycosylated core determinant (Core 1) with structure: Galβ1-3GalNAcα-O-Ser/Thr. In normal Mamalian cells, the TF determinant is masked by larger glycan residues. Once unmasked, TF serves as an important recognition element, mediating several cell-cell interactions. As such, TF is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered TF a potential target for cancer immunotherapy.
Keywords TF Antigen: H-Thr(Gal(beta(1-3)GalNAc)-OH, N-Acetyl-D-Galactosamine, O-Link, Disaccharide, Threonine, Free OH, Amino Acid, , TF Epitope (Threonine), T Antigen (Threonine), Galbeta(1-3)GalNAc-alpha-1-O-Threonine, Thomsen–Friedenreich Antigen, C18H32N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
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