Pack Size Price (USD) Availability Quantity
0.1mg$500.00In Stock
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0.25mg$750.00In Stock
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0.5mg$1,250.00In Stock
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FZD8 (541-549)-d8 labelled-STF(541)


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SKU: 08c058d6262c Categories: ,

Product #: GP000020

FZD8 (541-549)-d8 labelled-STF(541)

Product Details

Sequence T*V(d8)PAAVVVA-OH;
where T* = Thr* = Sialyl TF = STF = Neu5Acα2-3Galβ1-3GalNAcα-O-Thr
Other Names Frizzled-8, FZD8, APF-d8, Antiproliferative Factor (d8 isotope-labeled synthetic Glycopeptide)
UniProt ID Q9H461
Formula C63H100D7N11O29
Molecular Weight 1490.63
Purity >90% (HPLC)
Description FZD8(UniProt ID Q9H461) synthetic glycopeptide fragment(Thr541-Ala549; UniProt position 541-549, aa length 9) with Sialyl Tf (Neu5Acα2-3Galβ1-3GalNAc) at Thr541. Val542 has been labelled with d8. The C-terminus is carboxylic acid. Antiproliferative factor (APF) is a sialoglycopeptide that contains the transmembrane segment of Frizzled 8, a protein encoded by the FZD8 gene. Highly elevated levels of APF have been associated with interstitial cystitis. Abnormal Akt signaling in bladder epithelial cell explants from patients with interstitial cystitis/bladder pain syndrome can be induced by antiproliferative factor treatment of normal bladder cells.
Keywords FZD8 (541-549)-d8 labelled-STF(541), N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Threonine, Labelled, C-Terminus-Acid, STn-Glycopeptide, Formerly GP131025-d8, Frizzled-8, FZD8, APF-d8, Antiproliferative Factor (d8 isotope-labeled synthetic Glycopeptide), C63H100D7N11O29
Shipping Requirement Dry Ice
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