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Tn Antigen: Fmoc-Thr(GalNAc(Ac)3-α-D)-OH


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SKU: dabf488e0f73 Categories: ,

Product #: GA131000

Tn Antigen: Fmoc-Thr(GalNAc(Ac)3-α-D)-OH

Product Details

Other Names Tn Epitope (Threonine), Tn Antigen (Threonine, Fmoc, Peracetylated), Fmoc-Thr(α-D-GalNAc(Ac)3)-OH, Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, N-α-Fmoc-O-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine, N-(9-fluorenylmethoxycarbonyl)-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-galactopyranosyl)-L-threonine
CAS # 116783-35-8
Formula C33H38N2O13
Molecular Weight 670.66
Purity >95% (HPLC)
Description Tumor-Associated Carbohydrate Antigen (TACA). Tn is a truncated O-glycosylated core determinant with structure: GalNAcα-O-Ser/Thr. In normal Mamalian cells, the Tn determinant is masked by larger glycan residues. Once unmasked, Tn serves as an important recognition element, mediating several cell-cell interactions. As such, Tn is implicated in tumour cell organotropic metastasis. Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy.
Keywords Tn Antigen: Fmoc-Thr(GalNAc(Ac)3-alpha-D)-OH, N-Acetyl-D-Galactosamine, O-Link, Monosaccharide, Threonine, Blocked, Amino Acid, Ac, Tn Epitope (Threonine), Tn Antigen (Threonine, Fmoc, Peracetylated), Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, Fmoc-Thr(alpha-D-GalNAc(Ac)3)-OH, N-alpha-Fmoc-O-beta-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-galactopyranosyl)-L-threonine, N-(9-fluorenylmethoxycarbonyl)-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-galactopyranosyl)-L-threonine, C33H38N2O13, glycoamino acid, glycoamino acids, glyco amino acid, glycocosylated amino acids
References T. Ju, V.I. Otto and R.D. Cummings Angew. Chem. Int. Ed. 2011, 50, 1770 – 1791
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