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RPB1 CTD(1615-1621-Lys)-Tn(1619)


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SKU: b02ee7cbb120 Categories: ,

Product #: GP100095

RPB1 CTD(1615-1621-Lys)-Tn(1619)

Product Details

Sequence YSPTS*PSK-NH2;
where S* = Ser* = GalNAcα-O-Ser
Other Names RNA polymerase B at C-terminal domain(CTD), RPB1 CTD(Tn) glycopeptide
UniProt ID P24928
Formula C46H73N11O18
Molecular Weight 1068.1
Purity >90% (HPLC)
Description DNA-directed RNA polymerase II (Pol II) subunit RPB1 contains a Carboxy Terminal Domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. The CTD Nonconsensus Repeat, Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is heavily modified by phosphorylation, glycosylation and proline isomerization. The CTD acts as a tether to bring into close proximity the machinery necessary to synthesize and process Pol II transcripts.
Keywords RPB1 CTD(1615-1621-Lys)-Tn(1619), N-Acetyl-D-Galactosamine, O-Linked, Mono-Glycosylated, L-Serine, C-Terminus-Amide, Tn-Glycopeptide, Formerly GP121010, RNA polymerase B at C-terminal domain(CTD), RPB1 CTD(Tn) glycopeptide, C46H73N11O18
References Corden, J.L., Chem Rev. 2013; 113: 8423–8455.
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